Codeine is used for the short-term relief of mild to moderate pain. It should only be used when other forms of non-opioid pain relief have not been successful in managing pain. In general, if an opioid medicine is needed for pain relief, opioid medicines other than codeine are preferred, as they are more effective for most people.
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Methadone is part of a category of drugs called opioids. German doctors created it during World War II. When it came to the United States, doctors used it to treat people with extreme pain. Today, you might also get it as part of a treatment program for an addiction to heroin or narcotic painkillers.
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Tramadol, sold under the brand name Ultram among others, is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderately severe pain. When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour.
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